FFPE samples are essential for pathology and research but pose significant challenges in library preparation for next-generation sequencing (NGS) due to low inputs and chemical modification. These ...

In RNA-seq library preparation, selecting the appropriate number of PCR cycles is a critical balancing act to avoid overcycling.

New Ionic ® FFPE to Pure RNA Kit features simple, automated workflow for higher yields of pure RNA, including mRNA and miRNA, with less than five minutes of hands-on time per sample PLEASANTON, Calif.

Extraction of DNA and RNA from FFPE samples can be challenging, time consuming, and labor-intensive. Traditional methods of extraction require toxic chemicals, often resulting in degraded and ...

Validation of an exome and transcriptome based diagnostic platform enabling clinical cancer therapy selection and emerging composite biomarkers for immunotherapy. This is an ASCO Meeting Abstract from ...

Samples are commonly stored in a way that degrades RNA. Scientists are devising new ways to overcome this obstacle for RNA sequencing. RNA is more subject to degradation than DNA, whether chemical, ...

Martin highlights various factors impacting molecular analysis from FFPE samples and key challenges and considerations while working with this precious yet challenging sample type.

Formalin fixed paraffin-embedded (FFPE) tissue constitutes an enormous untapped resource for discovery, validation, and measurement of valuable biomarkers of disease progression, drug response, and ...

Reflex Testing for Germline BRCA1, BRCA2, PALB2, and ATM Mutations in Pancreatic Cancer: Mutation Prevalence and Clinical Outcomes From Two Canadian Research Registries Accurate transcriptional ...